Thanks for sharing this critically important information. So to be clear, zinc + ECGC + Ivermectin id the cocktail? Can you be more specific with dosing?
Hi Ann!! Thanks for your comment. I really can't say what dosing of IVM would be required to foster this extra expression of p53.
However, in general, physiological Oxidative Stressors (substances that cause cell damage, like UV light, cigarettes.. etc, etc) also (should) promote p53 expression. IVM may increase this amount even more, but it's hard to say from the In Vitro results.
I just found the article interesting, given increasing claims of IVM's anti-cancer abilities, and the link to our body's natural cancer fighting mechanisms.
As for dosing Zinc + EGCG, it depends upon whether its daily anticancer prophylaxis, or the antiviral Zelenko Protocol (4-5 days).. For daily Cancer and ROS inflammation reduction, as well as a sleep aid, Zinc can be supplemented up to 30-40mgs per day (220mg Zinc Sulfate). Your body will excrete any excess amounts.
But long-term, it would lead to Copper chelation, so you need to supplement your copper at a 1mg Cu to 10mg Zn ratio (based upon elemental forms so you need to check the labels. Copper is critical to properly brain function, and I'm currently digging into the "possibility" that mutated prions (think Mad Cow disease and CJD) may be the result of Copper deficiencies.
As for the EGCG, I generally take 200-400mg per day, via my Lemon Tea product I developed. It's about all I drink anymore throughout the day.
To simply this, just remember that p53 requires ZINC to properly function. All the other Zinc Ionophores do is help it enter our cells. "Zinc bullet to "gun" analogy that Zev popularized.
Those are some general guidelines, but the problem is everyone's bodies are different. If they are eating a lot of shellfish and crabs, or grass-fed Red Meats, they don't require nearly as much Zinc supplementation. And if you're eating those filter feeding shellfish, you probably don't need to worry about Copper supplementation either. Those creatures filter feed it out of the oceans and into their bodies and concentrate it there. But if you're sourcing it from an area with potential toxic chemicals, like mercury, then you have a major issue.
You are ALWAYS welcome to reach out to me..
And for those who don't know Ann, she was a good friend of Zev Zelenko, and he entrusted with a leadership role in the Zelenko Freedom Foundation. Worth following in her own right.
Reece - have you seen this excellent piece by Dr. Nagase, on the very alarming risks posed by infections of other species and the ability to survive outside the host?
So I keep hearing rumors about, but I can seem to find any definitive research on IVM having that capability. But I have no way of gauging the potency of that ability against others like HCQ, EGCG, or Quercetin. So I hesitate in recommending it for that purpose.
But it does have other antiviral qualities, in particular related to inhibition of Importin A/B, which can carry SARS-2 interferon suppressors across into the nucleus. We need that interferon "smoke alarm" response to trigger the immune reaction and SARS-2 appears to suppress it, providing it more time for unfettered replication.
As an RdRP inhibitor, I remain agnostic. This is primarily because I depend on the (evil?) genius of Ralph Baric and his use of ZINC, which is a critical element in our bodies, whereas IVM is not (and it's heavily restricted).
I'm not against it, and it clearly appears to show efficacy, according to FLCCC. I just want to apply Occam's Razor to the problem and focus on ingredients that are naturally used by our physiology, because that is how it evolved. Augmenting those natural minerals and vitamins should be the first step and, if necessary, using drugs like IVM to assist.
But I remain a graduate of the school of whatever works...
The role of ivermectin against the SARS-CoV-2 virus
The targets of activity of ivermectin can be divided into the following four groups:
A. Direct action on SARS-CoV-2
Level 1: Action on SARS-CoV-2 cell entry.
Level 2: Action on importin (IMP) superfamily.
Level 3: Action as an ionophore....
Taken from The Journal of Antibiotics
"The mechanisms of action of ivermectin against SARS-CoV-2—an extensive review"
Zaidi, A.K., Dehgani-Mobaraki, P. The mechanisms of action of ivermectin against SARS-CoV-2—an extensive review. J Antibiot 75, 60–71 (2022). https://doi.org/10.1038/s41429-021-00491-6
Thanks for sharing this critically important information. So to be clear, zinc + ECGC + Ivermectin id the cocktail? Can you be more specific with dosing?
Hi Ann!! Thanks for your comment. I really can't say what dosing of IVM would be required to foster this extra expression of p53.
However, in general, physiological Oxidative Stressors (substances that cause cell damage, like UV light, cigarettes.. etc, etc) also (should) promote p53 expression. IVM may increase this amount even more, but it's hard to say from the In Vitro results.
I just found the article interesting, given increasing claims of IVM's anti-cancer abilities, and the link to our body's natural cancer fighting mechanisms.
As for dosing Zinc + EGCG, it depends upon whether its daily anticancer prophylaxis, or the antiviral Zelenko Protocol (4-5 days).. For daily Cancer and ROS inflammation reduction, as well as a sleep aid, Zinc can be supplemented up to 30-40mgs per day (220mg Zinc Sulfate). Your body will excrete any excess amounts.
But long-term, it would lead to Copper chelation, so you need to supplement your copper at a 1mg Cu to 10mg Zn ratio (based upon elemental forms so you need to check the labels. Copper is critical to properly brain function, and I'm currently digging into the "possibility" that mutated prions (think Mad Cow disease and CJD) may be the result of Copper deficiencies.
As for the EGCG, I generally take 200-400mg per day, via my Lemon Tea product I developed. It's about all I drink anymore throughout the day.
To simply this, just remember that p53 requires ZINC to properly function. All the other Zinc Ionophores do is help it enter our cells. "Zinc bullet to "gun" analogy that Zev popularized.
Those are some general guidelines, but the problem is everyone's bodies are different. If they are eating a lot of shellfish and crabs, or grass-fed Red Meats, they don't require nearly as much Zinc supplementation. And if you're eating those filter feeding shellfish, you probably don't need to worry about Copper supplementation either. Those creatures filter feed it out of the oceans and into their bodies and concentrate it there. But if you're sourcing it from an area with potential toxic chemicals, like mercury, then you have a major issue.
You are ALWAYS welcome to reach out to me..
And for those who don't know Ann, she was a good friend of Zev Zelenko, and he entrusted with a leadership role in the Zelenko Freedom Foundation. Worth following in her own right.
Reece - have you seen this excellent piece by Dr. Nagase, on the very alarming risks posed by infections of other species and the ability to survive outside the host?
https://danielnagase.substack.com/p/japans-plan-to-destroy-the-world
and would your IVM protocols work to prevent/lower odds of infection or to cleanse the toxins if infected? Thank you - DT
Thanks!! I posted a response, and linked to my series "The Baric Files" for his readers.
We'll see what the impact is.
Thanks I look forward to reading it shortly. Very much grateful you took the time. Dt
Ivermectin is in and of itself a zinc ionophore .So is Hydroxychloroquine.
So I keep hearing rumors about, but I can seem to find any definitive research on IVM having that capability. But I have no way of gauging the potency of that ability against others like HCQ, EGCG, or Quercetin. So I hesitate in recommending it for that purpose.
But it does have other antiviral qualities, in particular related to inhibition of Importin A/B, which can carry SARS-2 interferon suppressors across into the nucleus. We need that interferon "smoke alarm" response to trigger the immune reaction and SARS-2 appears to suppress it, providing it more time for unfettered replication.
As an RdRP inhibitor, I remain agnostic. This is primarily because I depend on the (evil?) genius of Ralph Baric and his use of ZINC, which is a critical element in our bodies, whereas IVM is not (and it's heavily restricted).
I'm not against it, and it clearly appears to show efficacy, according to FLCCC. I just want to apply Occam's Razor to the problem and focus on ingredients that are naturally used by our physiology, because that is how it evolved. Augmenting those natural minerals and vitamins should be the first step and, if necessary, using drugs like IVM to assist.
But I remain a graduate of the school of whatever works...
The role of ivermectin against the SARS-CoV-2 virus
The targets of activity of ivermectin can be divided into the following four groups:
A. Direct action on SARS-CoV-2
Level 1: Action on SARS-CoV-2 cell entry.
Level 2: Action on importin (IMP) superfamily.
Level 3: Action as an ionophore....
Taken from The Journal of Antibiotics
"The mechanisms of action of ivermectin against SARS-CoV-2—an extensive review"
Zaidi, A.K., Dehgani-Mobaraki, P. The mechanisms of action of ivermectin against SARS-CoV-2—an extensive review. J Antibiot 75, 60–71 (2022). https://doi.org/10.1038/s41429-021-00491-6